Ebiosciences 17-5149-42 Anti-Human Cd85D (Ilt4) Apc, 100 Tests

Ebiosciences 17-5149-42 Anti-Human Cd85D (Ilt4) Apc, 100 Tests

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  • The monoclonal antibody 42D1 recognizes the CD85d protein also known as ILT4, LIR-2
  • It is a member of the ILT (immunoglobulin-like transcript)/ LIR (leukocyte Ig-like receptor), MIR (monocytes Ig-like receptor) family
  • CD85d is a 110 kDa single transmembrane receptor with 3 Ig-like domains and a long cytoplasmic domain containing ITIMs (immunoreceptor tyrosine-based inhibitory motifs)
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The monoclonal antibody 42D1 recognizes the CD85d protein also known as ILT4, LIR-2. It is a member of the ILT (immunoglobulin-like transcript)/ LIR (leukocyte Ig-like receptor), MIR (monocytes Ig-like receptor) family. CD85d is a 110 kDa single transmembrane receptor with 3 Ig-like domains and a long cytoplasmic domain containing ITIMs (immunoreceptor tyrosine-based inhibitory motifs). Expression is confined to monocytes, macrophages and dendritic cells. The ligand for CD85d is non-classical class I HLA-G, -B and G1. Upon ligand binding, tyrosine phosphatase SHP-1 interacts with the ITIM. Interaction of HLA-G with ILT4/CD85d is thought to contribute to tolerance during fetal implantation. Additionally, it is the levels of ILT3 and ILT4 on DCs that suggests a role in organ allograft rejection. Crosslinking of the receptor with the monoclonal antibody 42D1 inhibits calcium flux as well as enhancing HLA-G tetramer staining and restoring the stimulating activity of tolerogenic DC.

  • The monoclonal antibody 42D1 recognizes the CD85d protein also known as ILT4, LIR-2
  • It is a member of the ILT (immunoglobulin-like transcript)/ LIR (leukocyte Ig-like receptor), MIR (monocytes Ig-like receptor) family
  • CD85d is a 110 kDa single transmembrane receptor with 3 Ig-like domains and a long cytoplasmic domain containing ITIMs (immunoreceptor tyrosine-based inhibitory motifs)
Binding

Misc.

Brand

eBiosciences

Label

eBioScience

Manufacturer

eBioScience

Model

17-5149-42

MPN

17-5149-42

PartNumber

17-5149-42

ProductGroup

BISS

ProductTypeName

LAB_SUPPLY

Publisher

eBioScience

Studio

eBioScience

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