Ebiosciences 16-0333-82 Anti-Mouse Siglec H Functional Grade Purified, 100 Ug

Ebiosciences 16-0333-82 Anti-Mouse Siglec H Functional Grade Purified, 100 Ug

Mcfarland by Ly Domain
  • The monoclonal antibody eBio440c recognizes Siglec-H, a protein exclusively found on pDC (plasmacytoid dendritic cells) or type I IFN-producing cells (IPC) in the naive mouse
  • Mouse IPC are typically PDCAplus, CD11cplus, CD11b-, B220plus, and Ly-6Cplus, and are quick to respond to viruses
  • Siglec-H is a transmembrane protein of the Ig superfamily that like CD33 have been shown to bind sialic acid but lacks the characteristic cytoplasmic ITIM domain (immunoreceptor tyrosine based inhibitory motif)
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Ebiosciences 16-0333-82 Anti-Mouse Siglec H Functional Grade Purified, 100 Ug is a part of Ly Domain products library. To see this Ebiosciences 16-0333-82 Anti-Mouse Siglec H Functional Grade Purified, 100 Ug in stock for product, click the link above and come over and then you will get this item about Ebiosciences 16-0333-82 Anti-Mouse Siglec H Functional Grade Purified, 100 Ug .


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The monoclonal antibody eBio440c recognizes Siglec-H, a protein exclusively found on pDC (plasmacytoid dendritic cells) or type I IFN-producing cells (IPC) in the naive mouse. Mouse IPC are typically PDCAplus, CD11cplus, CD11b-, B220plus, and Ly-6Cplus, and are quick to respond to viruses. Siglec-H is a transmembrane protein of the Ig superfamily that like CD33 have been shown to bind sialic acid but lacks the characteristic cytoplasmic ITIM domain (immunoreceptor tyrosine based inhibitory motif). To overcome the lack of a cytoplasmic domain, Siglec-H associates with DAP12 thereby allowing for signal transduction. The eBio440c antibody has been shown to inhibit pDC function (inhibits IFN alpha secretion in response to CpG).It has been observed that some mouse strains (such as SJL) have higher percentages of pDCs compared to C57BL/6.

  • The monoclonal antibody eBio440c recognizes Siglec-H, a protein exclusively found on pDC (plasmacytoid dendritic cells) or type I IFN-producing cells (IPC) in the naive mouse
  • Mouse IPC are typically PDCAplus, CD11cplus, CD11b-, B220plus, and Ly-6Cplus, and are quick to respond to viruses
  • Siglec-H is a transmembrane protein of the Ig superfamily that like CD33 have been shown to bind sialic acid but lacks the characteristic cytoplasmic ITIM domain (immunoreceptor tyrosine based inhibitory motif)
  • 0
Binding

Misc.

Brand

eBiosciences

Label

eBioScience

Manufacturer

eBioScience

Model

16-0333-82

MPN

16-0333-82

PartNumber

16-0333-82

ProductGroup

BISS

ProductTypeName

LAB_SUPPLY

Publisher

eBioScience

Studio

eBioScience

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