Sendai Virus Vector: Advantages And Applications

Sendai Virus Vector: Advantages And Applications

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Sendai virus (SeV) is not just a mouse pathogen but is evolving into a cutting-edge component of biotechnology. SeV reverse genetics originating from a pure academic need to settle long-held questions in the biology and pathogenicity of nonsegmented negative strand RNA viruses (Mononegavirales) is about to bear the impressive fruit of multipurpose cytoplasmic (non-integrating) RNA vectors. This book brings together in one source the SeV biology revealed by conventional approaches and reverse genetics, the methods to construct the first-generation SeV vector and to generate safer versions, and the applications in medical settings that have left or are about to leave the laboratory bench. The applications, which already are diverse and have high medical impact, include use as vaccine vectors against AIDS and respiratory virus infections, creation of BioKnife to resect malignant tumors, induction of “footprint (transgene) free” pluripotent stem cells, and gene therapy for peripheral arterial disease. These achievements—which are just a few of many examples—were attainable only after rigorously incorporating the rich knowledge of SeV biology that has accumulated during the several decades since the discovery of the virus. Application of SeV vector is certain to expand greatly because of its extremely high performance in transgene expression and its remarkable target cell breadth.

    Binding

    Hardcover

    Creator

    Yoshiyuki Nagai

    EAN

    9784431545552

    Edition

    2013

    ISBN

    4431545557

    Label

    Springer

    Manufacturer

    Springer

    NumberOfPages

    210

    ProductGroup

    Book

    ProductTypeName

    ABIS_BOOK

    PublicationDate

    2014-01-31

    Publisher

    Springer

    Studio

    Springer

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